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November 1, 1989Annals of Internal Medicine

Home Prothrombin Time Monitoring after the Initiation of Warfarin Therapy

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Why the study?

Does home prothrombin time monitoring improve time in therapeutic range compared to specialized clinic care in patients initiating warfarin?

Population

50 outpatients discharged from a university or community hospital, started on warfarin for the first time…

Comparison

Oral anticoagulation therapy managed using a… vs Specialized anticoagulation clinic care

Design

RCT, Randomized

Follow-up

8 weeks

Authors

RWRichard H. WhiteUniversity of California, Davis

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Implication

Home monitoring improves TTR in warfarin initiators; supports adoption and extends self-monitoring evidence.

Structured PICO

Does home prothrombin time monitoring improve time in therapeutic range compared to specialized clinic care in patients initiating warfarin?

P
Population
50 outpatients discharged from a university or community hospital, started on warfarin for the first time, who demonstrated ability to use the monitor and had not achieved a stable response in the hospital.
I
Intervention
Oral anticoagulation therapy managed using a portable prothrombin time monitor at home
C
Comparator
Specialized anticoagulation clinic care
O
Outcome
Percentage of time within a range equal to the target prothrombin ratio +/- 0.3 (always above 1.25)surrogate

Home prothrombin time monitoring is feasible, accurate, and provides superior anticoagulation control compared to standard clinic care for patients initiating warfarin.

Cite This Study

Richard H. White (1989) studied this question.

synapsesocial.com/papers/6a7ccfee6d245ff91d66e5behttps://doi.org/10.7326/0003-4819-111-9-730
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Novel Whole Blood Capillary Technic for Measuring the Prothrombin Time1987 · 91 citations
  2. 2Therapeutic control of anticoagulant treatment.1982 · 43 citations
  3. 3Assessment of Therapeutic Control of Anticoagulation2009 · 27 citations
  4. 4Management of Oral Anticoagulant Therapy1984 · 98 citations
  5. 5Management of Anticoagulation in Outpatients1977 · 89 citations