Why the study?
Does insulin stimulation affect adiponectin gene expression in adipose tissue explants from subjects with morbid obesity?
Population
20 subjects (10 men and 10 women) with morbid obesity
Comparison
Insulin stimulation of isolated adipocytes from… vs Control conditions (no insulin stimulation)
Design
Preclinical
Authors
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Insulin may upregulate omental adiponectin more in metabolic syndrome; leaves open in vivo relevance and therapeutic translation.
Does insulin stimulation affect adiponectin gene expression in adipose tissue explants from subjects with morbid obesity?
Insulin stimulates adiponectin gene expression in a depot-specific manner, particularly in visceral tissue of individuals with impaired insulin sensitivity.
Morante et al. (2008) studied this question.
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