What question did this study set out to answer?

To assess acute renal outcomes in older adults within 90 days of initiating fibrate therapy compared with ezetimibe.

April 17, 2012Annals of Internal Medicine

New Fibrate Use and Acute Renal Outcomes in Elderly Adults

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Authors

YZYing Zhao

Discussion

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Overview

Population-based cohort study reveals increased risk of creatinine elevation and hospitalization in older adults starting fibrates, highlighting the need for careful renal monitoring.

Key Points

To assess acute renal outcomes in older adults within 90 days of initiating fibrate therapy compared with ezetimibe.
Population-based cohort study conducted in Ontario, Canada, among patients aged 66 years or older with a new outpatient prescription for a fibrate (n = 19,072) or ezetimibe (n = 61,831) between 2004 and 2008.
The primary outcome was hospitalization for an increase in serum creatinine within 90 days; secondary outcomes included nephrologist consultations, dialysis for severe acute kidney injury, and all-cause mortality.
Fibrate users had a higher risk of hospitalization for increased serum creatinine (adjusted OR 2.4, 95% CI 1.7 to 3.3) and were more likely to consult a nephrologist (adjusted OR 1.3, 95% CI 1.0 to 1.6; absolute risk difference 0.15%, 95% CI 0.01% to 0.29%).
In a subpopulation with routine laboratory testing (n = 1,110), an increase in serum creatinine of ≥50% occurred in 9.1% of fibrate users compared with 0.3% of ezetimibe users (OR 29.6, 95% CI 8.7 to 100.5; absolute difference 8.8%, 95% CI 4.5% to 13.1%).
Fibrate initiation was not associated with an increased risk of dialysis for severe acute kidney injury or all-cause mortality, though creatinine elevation risks were greater among patients with baseline chronic kidney disease.

Cite This Study

Ying Zhao (2012) studied this question.

synapsesocial.com/papers/6a7cd11948a1093064cc0eba https://doi.org/10.7326/0003-4819-156-8-201204170-00401

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April 17, 2012Annals of Internal Medicine

New Fibrate Use and Acute Renal Outcomes in Elderly Adults

View Full Paper

Ask AI

Bookmark

Authors

YZYing Zhao

Discussion

Member takes

Overview

Population-based cohort study reveals increased risk of creatinine elevation and hospitalization in older adults starting fibrates, highlighting the need for careful renal monitoring.

Key Points

To assess acute renal outcomes in older adults within 90 days of initiating fibrate therapy compared with ezetimibe.
Population-based cohort study conducted in Ontario, Canada, among patients aged 66 years or older with a new outpatient prescription for a fibrate (n = 19,072) or ezetimibe (n = 61,831) between 2004 and 2008.
The primary outcome was hospitalization for an increase in serum creatinine within 90 days; secondary outcomes included nephrologist consultations, dialysis for severe acute kidney injury, and all-cause mortality.
Fibrate users had a higher risk of hospitalization for increased serum creatinine (adjusted OR 2.4, 95% CI 1.7 to 3.3) and were more likely to consult a nephrologist (adjusted OR 1.3, 95% CI 1.0 to 1.6; absolute risk difference 0.15%, 95% CI 0.01% to 0.29%).
In a subpopulation with routine laboratory testing (n = 1,110), an increase in serum creatinine of ≥50% occurred in 9.1% of fibrate users compared with 0.3% of ezetimibe users (OR 29.6, 95% CI 8.7 to 100.5; absolute difference 8.8%, 95% CI 4.5% to 13.1%).
Fibrate initiation was not associated with an increased risk of dialysis for severe acute kidney injury or all-cause mortality, though creatinine elevation risks were greater among patients with baseline chronic kidney disease.

Cite This Study

Ying Zhao (2012) studied this question.

synapsesocial.com/papers/6a7cd11948a1093064cc0eba https://doi.org/10.7326/0003-4819-156-8-201204170-00401

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