October 18, 2016The Korean Journal of Internal MedicineOpen Access

Two-year clinical outcomes in stable angina and acute coronary syndrome after percutaneous coronary intervention of left main coronary artery disease

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Why the study?

Does percutaneous coronary intervention for unprotected left main coronary artery disease yield similar 2-year clinical outcomes in patients with acute coronary syndrome compared to those with stable angina pectoris?

Structured PICO

Population

448 consecutive patients who underwent percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) disease, mean age 64 ± 10 years, 75.7% male (n=339), based in Korea. The cohort was divided into stable angina pectoris (SAP, n=60) and acute coronary syndrome (ACS, n=388).

Intervention

Percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) disease in patients presenting with acute coronary syndrome (ACS)

Comparator

Percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) disease in patients presenting with stable angina pectoris (SAP)

Outcome

Major adverse cardiac events (MACE) at 2-year clinical follow-up, defined as a composite of target lesion revascularization (TLR), target vessel revascularization (TVR), non-TVR, CABG, myocardial infarction (MI), and deathcomposite

Although in-hospital mortality is higher in ACS patients undergoing PCI for unprotected left main coronary artery disease, their 2-year clinical outcomes are similar to those of patients with stable angina.

Limitations

Did not show data on clinical follow-up beyond 2 years to document longer-term safety
Retrospective study design

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Comparable 2-year outcomes after unprotected left main PCI in ACS versus SAP; leaves open confounding by indication in this observational cohort.

Cite This Study

Hyun et al. (2016) studied this question.

synapsesocial.com/papers/6a7cd384277f61b5c55dfe59 https://doi.org/10.3904/kjim.2014.373

Topics

Coronary artery disease Percutaneous coronary intervention Chronic total occlusion PCI

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Implication

Comparable 2-year outcomes after unprotected left main PCI in ACS versus SAP; leaves open confounding by indication in this observational cohort.

Two-year clinical outcomes in stable angina and acute coronary syndrome after percutaneous coronary intervention of left main coronary artery disease

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

Two-year clinical outcomes in stable angina and acute coronary syndrome after percutaneous coronary intervention of left main coronary artery disease

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider