Why the study?
The study aimed to evaluate the utility of NT-proBNP, MR-proANP, and adiponectin in monitoring left ventricular reverse remodeling, reverse electrical remodeling, and clinical response after CRT in refractory heart failure.
Do changes in NT-proBNP, MR-proANP, and adiponectin levels correlate with left ventricular reverse remodeling, reverse electrical remodeling, and clinical response in heart failure patients receiving cardiac resynchronization therapy?
Do changes in NT-proBNP, MR-proANP, and adiponectin levels correlate with left ventricular reverse remodeling, reverse electrical remodeling, and clinical response in heart failure patients receiving cardiac resynchronization therapy?
Reductions in MR-proANP and adiponectin levels following CRT correlate with left ventricular reverse remodeling and reverse electrical remodeling, suggesting their potential utility as biomarkers for monitoring CRT response.
May aid CRT response monitoring in refractory HF; leaves open prospective validation of these biomarkers.
Introduction: Cardiac resynchronization therapy (CRT), is a therapeutic option for patients with refractory heart failure. We aimed to examine the usefulness of N-terminal pro-brain-type natriuretic peptide (NT-proB-NP), mid-regional pro-atrial natriuretic peptide (MR-proANP), and adiponectin in monitoring CRT-induced left ventricular (LV) reverse remodeling, reverse electrical remodeling, and clinical response.
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Polat et al. (2021) studied this question.
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