What question did this study set out to answer?

Investigate whether cellular magnesium depletion induces digitalis-toxic arrhythmias in patients with normal serum digoxin and determine the efficacy of magnesium sulfate therapy.

May 27, 1983JAMA

Magnesium Sulfate and Digitalis-Toxic Arrhythmias

View Full Paper

Ask AI

Bookmark

Authors

LCLeon CohenTechnion – Israel Institute of Technology

Discussion

Member takes

Implication

Case series demonstrates that magnesium sulfate abolishes digitalis-toxic arrhythmias in heart failure patients, indicating cellular magnesium depletion triggers toxicity despite normal blood levels.

Key Points

Investigate whether cellular magnesium depletion induces digitalis-toxic arrhythmias in patients with normal serum digoxin and determine the efficacy of magnesium sulfate therapy.
Evaluated N=7 patients with congestive heart failure on long-term diuretic therapy (>3 years) presenting with idionodal tachycardia and normal serum digoxin levels.
Administered intravenous bolus magnesium sulfate followed by intramuscular magnesium repletion while assessing serum electrolytes alongside lymphocyte magnesium and potassium contents.
Intravenous bolus magnesium sulfate followed by intramuscular repletion successfully abolished idionodal tachycardia across all seven patients.
Lymphocyte magnesium and potassium levels were markedly decreased in all patients, demonstrating cellular magnesium depletion despite normal serum magnesium concentrations in five patients and hypomagnesemia in two.

Cite This Study

Leon Cohen (1983) studied this question.

synapsesocial.com/papers/6a7cdbfeccf86f44befebf30 https://doi.org/10.1001/jama.1983.03330440046030

View Full Paper

Ask AI

Bookmark

Implication

Case series demonstrates that magnesium sulfate abolishes digitalis-toxic arrhythmias in heart failure patients, indicating cellular magnesium depletion triggers toxicity despite normal blood levels.

Magnesium Sulfate and Digitalis-Toxic Arrhythmias

Discussion

Member takes

Implication

Key Points

Cite This Study

Magnesium Sulfate and Digitalis-Toxic Arrhythmias

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider