February 4, 2009The Journal of Clinical Endocrinology & Metabolism
Cardiovascular and Cerebrovascular Comorbidities of Hypokalemic and Normokalemic Primary Aldosteronism: Results of the German Conn’s Registry
Why the study?
Does hypokalemic primary aldosteronism increase cardiovascular and cerebrovascular comorbidities compared to normokalemic primary aldosteronism in patients with primary aldosteronism?
Population
553 patients with primary aldosteronism (mean age 61 +/- 13 yr, range 13-96) from six German centers
Comparison
Hypokalemic primary aldosteronism vs Normokalemic primary aldosteronism
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May warrant heightened cardiovascular vigilance in hypokalemic PA; leaves open whether hypokalemia is causal or modifiable.
Structured PICO
Does hypokalemic primary aldosteronism increase cardiovascular and cerebrovascular comorbidities compared to normokalemic primary aldosteronism in patients with primary aldosteronism?
P
Population
553 patients with primary aldosteronism (mean age 61 +/- 13 yr, range 13-96) from six German centers
I
Intervention
Hypokalemic primary aldosteronism
C
Comparator
Normokalemic primary aldosteronism
O
Outcome
Differences in cardiovascular and cerebrovascular comorbidities depending on hypokalemia or normokalemiahard clinical
Hypokalemic primary aldosteronism is associated with a higher prevalence of certain cardiovascular comorbidities compared to the normokalemic variant, though both groups exhibit high excess morbidity.
Cite This Study
Born-Frontsberg et al. (2009) studied this question.