Why the study?
Pressure distortions and measurement location may influence FFR INV interpretation, prompting evaluation of a technique to minimize distortions and identify the proper measurement location.
Does the site of pressure measurement and technique influence the interpretation of invasive fractional flow reserve in coronary arteries?
Population
100 normal and diseased coronary arteries with single stenosis
Comparison
Measurements across terminal vessel, distal-to-the-lesion, proximal vessel, and guiding catheter
Design
Prospective cohort study
Authors
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Minimizing FFR pressure distortions may improve measurement reliability in practice; leaves open validation against clinical outcomes in larger cohorts.
Does the site of pressure measurement and technique influence the interpretation of invasive fractional flow reserve in coronary arteries?
Measuring FFR 20 to 30 mm distal to the lesion rather than in the terminal vessel, along with meticulous technique, reduces measurement errors and prevents overestimation of lesion-specific ischemia.
Renard et al. (2019) studied this question.
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