Leg length, insulin resistance, and coronary heart disease risk: The Caerphilly Study
Why the study?
Is leg length associated with insulin resistance and the risk of coronary heart disease in middle-aged men?
Population
2512 men aged 45-59 years living in Caerphilly, South Wales
Design
Cohort
Follow-up
15 years
Authors
Discussion
Loading...
Member takes
Implication
Suggests early-life growth influences adult CHD risk; extends observational data but remains hypothesis-generating without causal confirmation.
Structured PICO
Is leg length associated with insulin resistance and the risk of coronary heart disease in middle-aged men?
P
Population
2512 men aged 45-59 years living in Caerphilly, South Wales
I
Intervention
Leg length (exposure)
O
Outcome
Cumulative incidence of coronary heart disease (fatal and non-fatal)hard clinical
Shorter leg length in adulthood is associated with an adverse insulin resistance profile and increased risk of coronary heart disease, suggesting pre-adult influences on cardiovascular risk.
Cite This Study
George Davey Smith (2001) studied this question.