Efficacy and Safety of Subcutaneous Infusion of Non-formulated Furosemide in Patients with Worsening Heart Failure: a Real-World Study
Why the study?
To evaluate the efficacy on decongestion surrogates and safety following the ambulatory administration of subcutaneous furosemide in patients with worsening heart failure.
Does subcutaneous furosemide improve surrogates of decongestion and safety in ambulatory patients with worsening heart failure?
Comparison
Subcutaneous furosemide administered by an elastomeric pump for at least 72 h
Design
Real-world study
Follow-up
30 days
Authors
Discussion
Loading...
Member takes
Implication
May enable ambulatory WHF decongestion; hypothesis-generating and requires randomized confirmation.
Structured PICO
Does subcutaneous furosemide improve surrogates of decongestion and safety in ambulatory patients with worsening heart failure?
P
Population
55 ambulatory patients with worsening heart failure (WHF)
I
Intervention
Subcutaneous furosemide administered by an elastomeric pump for at least 72 h (median dose of 100 mg/daily)
O
Outcome
Short-term changes in surrogates of decongestion and safety assessed at 72 h and 30 dayssurrogate
Subcutaneous infusion of non-formulated furosemide via elastomeric pump is an effective and safe strategy for outpatient congestion management in worsening heart failure.
Cite This Study
Civera et al. (2021) studied this question.