Why the study?
Does SRF/myocardin inhibition reduce aortic stiffness and blood pressure in spontaneously hypertensive rats?
Does SRF/myocardin inhibition reduce aortic stiffness and blood pressure in spontaneously hypertensive rats?
Pharmacological inhibition of the SRF/myocardin signaling pathway reduces aortic stiffness and blood pressure in hypertensive rats, presenting a potential novel therapeutic target.
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Hypothesis-generating for SRF/myocardin inhibition in hypertension; human trials needed before any clinical consideration.
Zhou et al. (2016) studied this question.
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