Key result
STARS activates serum response factor (SRF) by inducing the RhoA- and actin polymerization-dependent nuclear translocation of myocardin-related transcription factors in striated muscle cells.
STARS links actin dynamics and sarcomere structure with striated muscle gene expression by promoting the nuclear localization of MRTFs and SRF-mediated transcription.
No takes yet. Share an insight, caveat, or question.
May link actin dynamics to striated muscle transcription in models; leaves open human disease relevance.
Kuwahara et al. (2005) studied this question. STARS (striated muscle activator of Rho signaling) was evaluated on Nuclear translocation of MRTFs and SRF activity. STARS activates serum response factor (SRF) by inducing the RhoA- and actin polymerization-dependent nuclear translocation of myocardin-related transcription factors in striated muscle cells.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: