Key result
Forced overexpression of STARS in the heart sensitizes it to pressure overload, resulting in an exaggerated decrease in ejection fraction (44.9% vs 82.1% in wild-type) and increased mortality.
Absolute Event Rate: 44.9% vs 82.1%
p-value: p=<0.05
STARS acts as a cytoskeletal intermediary between MEF2 and SRF, and its overexpression sensitizes the heart to biomechanical stress and calcineurin signaling, exacerbating cardiac dysfunction.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating in murine pressure overload; leaves open STARS as a therapeutic target in human heart failure.
Kuwahara et al. (2007) studied Cardiac hypertrophy and cardiomyopathy. STARS overexpression vs. Wild-type / non-transgenic controls was evaluated on Ejection fraction after thoracic aortic banding (TAB) (p=<0.05). Forced overexpression of STARS in the heart sensitizes it to pressure overload, resulting in an exaggerated decrease in ejection fraction (44.9% vs 82.1% in wild-type) and increased mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: