What question did this study set out to answer?

To evaluate whether contrast-enhanced multidetector CT can characterize myocardial scar and border zones and integrate 3D reconstructions into clinical mapping systems to guide ventricular tachycardia ablation.

July 26, 2010Circulation Arrhythmia and Electrophysiology

Three-Dimensional Contrast-Enhanced Multidetector CT for Anatomic, Dynamic, and Perfusion Characterization of Abnormal Myocardium To Guide Ventricular Tachycardia Ablations

View Full Paper

Ask AI

Bookmark

Why the study?

Does three-dimensional contrast-enhanced multidetector CT accurately characterize abnormal myocardium and predict voltage-defined scar to guide ventricular tachycardia ablation in patients with ischemic cardiomyopathy?

Population

11 patients with ischemic cardiomyopathy undergoing ventricular tachycardia ablation

Comparison

Three-dimensional contrast-enhanced… vs Voltage mapping (endocardial voltages <1.5 mV)

Design

Cohort

Authors

JTJing TianCentral South University JJJean JeudyCardiac Imaging MSMark F. SmithUniversity of Maryland, Baltimore

Discussion

Member takes

Implication

CT scar mapping may aid VT ablation planning in ischemic cardiomyopathy; leaves open prospective validation of clinical utility.

Key Points

To evaluate whether contrast-enhanced multidetector CT can characterize myocardial scar and border zones and integrate 3D reconstructions into clinical mapping systems to guide ventricular tachycardia ablation.
Evaluated segmental anatomic (wall thickness), dynamic (wall thickening, motion), and perfusion (hypoenhancement) features using contrast-enhanced CT in 11 patients with ischemic cardiomyopathy before ablation.
Reconstructed 3D epicardial and endocardial surfaces and scar borders, coregistered them to clinical mapping systems, and compared findings with invasive electroanatomical voltage data across a 17-segment model.
Abnormal CT anatomic, dynamic, and perfusion metrics correlated well with abnormal (<1.5 mV) endocardial voltages (r=0.77).
Integrated 3D CT models (registration accuracy, 3.31±0.52 mm) predicted homogeneous abnormal voltage in 81.7% of segments and correctly demonstrated transmural and intramural scar extent.
CT hypoperfusion correlated best with scar and border zone areas and encompassed curative ablation sites in 82% of cases.

Structured PICO

Population

11 patients with ischemic cardiomyopathy undergoing ventricular tachycardia ablation

Intervention

Three-dimensional contrast-enhanced multidetector CT with integration of scar reconstructions into clinical mapping systems

Comparator

Voltage mapping (endocardial voltages <1.5 mV)

Outcome

Correlation of segmental anatomic, dynamic, and perfusion characteristics with abnormal endocardial voltages (<1.5 mV)surrogate

Contrast-enhanced multidetector CT can accurately characterize myocardial scar and border zones, correlating well with voltage mapping to potentially guide ventricular tachycardia ablation.

Cite This Study

Tian et al. (2010) studied this question.

synapsesocial.com/papers/6a7cddfa033ca1e0093e151b https://doi.org/10.1161/circep.109.889311

Topics

Ventricular arrhythmias Women and heart disease AF ablation outcomes

View Full Paper

Ask AI

Bookmark

Three-Dimensional Contrast-Enhanced Multidetector CT for Anatomic, Dynamic, and Perfusion Characterization of Abnormal Myocardium To Guide Ventricular Tachycardia Ablations

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Three-Dimensional Contrast-Enhanced Multidetector CT for Anatomic, Dynamic, and Perfusion Characterization of Abnormal Myocardium To Guide Ventricular Tachycardia Ablations

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider