December 25, 2007Hypertension
Metabolic Syndrome and Vascular Alterations in Normotensive Subjects at Risk of Diabetes Mellitus
Why the study?
Is the presence of metabolic syndrome associated with early vascular abnormalities in normotensive subjects at risk of developing diabetes mellitus?
Population
127 subjects, comprising 77 normotensive subjects at risk of developing diabetes mellitus and 50 healthy…
Comparison
Presence of Metabolic Syndrome defined according… vs Subjects without Metabolic Syndrome and healthy…
Design
Cross-sectional
Authors
Discussion
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Implication
Hypothesis-generating for early vascular changes in normotensive metabolic syndrome; prospective studies needed before clinical adoption.
Structured PICO
Is the presence of metabolic syndrome associated with early vascular abnormalities in normotensive subjects at risk of developing diabetes mellitus?
P
Population
127 subjects, comprising 77 normotensive subjects (mean age 50 years) at risk of developing diabetes mellitus (due to family history of diabetes, obesity, or impaired fasting glucose) and 50 healthy controls.
I
Intervention
Presence of Metabolic Syndrome (MS) defined according to ATP III criteria.
C
Comparator
Subjects without Metabolic Syndrome and healthy controls.
O
Outcome
Early vascular abnormalities assessed by brachial artery flow-mediated dilation (FMD), response to glyceryl trinitrate (GTN), carotid-femoral pulse wave velocity (PWV), and radial augmentation index (AIx).surrogate
In normotensive subjects at risk of developing diabetes, the presence of metabolic syndrome is independently associated with increased central arterial stiffness as measured by pulse wave velocity.
Cite This Study
Ghiadoni et al. (2007) studied this question.