Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes
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Key result
Metabolic syndrome was significantly associated with increased subclinical atherosclerosis markers, including higher brachial-ankle pulse wave velocity and carotid intima-media thickness, only in individuals without diabetes.
Why the study?
Does the presence of metabolic syndrome exacerbate subclinical atherosclerosis differently in patients with versus without diabetes?
Population
2,560 adults participating in baseline health examinations for a community-based cohort study in the Seoul…
Comparison
Presence of metabolic syndrome and its… vs Absence of metabolic syndrome
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May support atherosclerosis monitoring for metabolic syndrome in non-diabetics but not diabetes; hypothesis-generating.
Study Design
Type
Cross-Sectional (n=2,560)
Structured PICO
Does the presence of metabolic syndrome exacerbate subclinical atherosclerosis differently in patients with versus without diabetes?
P
Population
2,560 adults (mean age 60 years, 67% female) free of prior cardiovascular disease who participated in baseline health examinations for a community-based cohort study in Korea.
E
Exposure
Presence of metabolic syndrome (MS) and its individual components
C
Comparator
Absence of metabolic syndrome
O
Outcome
Surrogate markers of subclinical atherosclerosis: brachial-ankle pulse wave velocity (baPWV), carotid intima-medial thickness (IMT), and presence of carotid plaquesurrogate
Main Result
Absolute Event Rate: 1562% vs 1438%
p-value: p=<0.001
Metabolic syndrome significantly exacerbates subclinical atherosclerosis in non-diabetic individuals, whereas in established diabetes, the presence of metabolic syndrome does not confer additional atherosclerotic burden.
Limitations
- Criteria of MS might be dependent on race and ethnicity as the study included only a Korean population
- Impact of MS on the progression of atherosclerosis might differ according to age group
- Physical activity of participants was not evaluated
- Relatively few subjects with diabetes compared to those without diabetes
- Observational design cannot eliminate possible effects of underlying disease and medication
- Degree of hyperglycemic control using HbA1c was not evaluated in diabetic patients
- Criteria of MS might be dependent on race and ethnicity (only Korean population included)
- No sub-analysis of SCA according to age group
- Physical activity of participants not evaluated
- Relatively few subjects with diabetes
- Degree of hyperglycemic control using HbA1c not evaluated
Cite This Study
Won et al. (2013) conducted a cross-sectional in Metabolic Syndrome and Subclinical Atherosclerosis (n=2,560). Metabolic syndrome vs. No metabolic syndrome was evaluated on Brachial-ankle pulse wave velocity (baPWV) in non-diabetic subjects (p=<0.001). Metabolic syndrome was significantly associated with increased subclinical atherosclerosis markers, including higher brachial-ankle pulse wave velocity and carotid intima-media thickness, only in individuals without diabetes.
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