Key result
Metabolic syndrome was associated with increased carotid intima-media thickness and decreased carotid artery compliance compared to those without the syndrome.
Why the study?
Does metabolic syndrome associate with subclinical atherosclerosis in young adults?
Observational (n=2,163)
Does metabolic syndrome associate with subclinical atherosclerosis in young adults?
Metabolic syndrome in young adults is associated with increased subclinical atherosclerosis, and this association is modified by endothelial function.
Answers are grounded in this paper and cite their sources.
May warrant vascular assessment in young adults with metabolic syndrome; extends observational links to this age group but remains hypothesis-generating.
AIMS: To study the relations between the metabolic syndrome (MS) and subclinical atherosclerosis in young adults. METHODS AND RESULTS: International Diabetes Federation (msIDF), National Institute of Health Adult Treatment Panel III (msNCEP), and European Group for the Study of Insulin Resistance (msEGIR) definitions of MS were related to carotid artery intima-media thickness (cIMT), brachial flow-mediated dilatation (FMD), and carotid artery compliance (CAC) in 2163 Finnish adults (aged 32 +/- 5years). All definitions associated with increased cIMT and decreased CAC in both sexes. The cIMT values (mean+/-SD) were 0.576 +/- 0.088 mm in subjects without the syndrome, 0.615 +/- 0.102 mm in msIDF, 0.617 +/- 0.104 mm in msNCEP, and 0.607 +/- 0.097 mm in msEGIR (P < 0.0001). Corresponding CAC values were 2.26 +/- 0.72, 1.76 +/- 0.66, 1.73 +/- 0.66, 1.72 +/- 0.66%/10 mmHg (P < 0.001). Impaired brachial FMD was not related to MS but it modified the relations between MS and cIMT: MS correlated with increased cIMT in subjects with an impaired FMD response (P = 0.003) but not in subjects with an enhanced FMD response (P = 0.75). CONCLUSION: All current definitions of MS identify a population of young adults with evidence of increased subclinical atherosclerosis. Impaired brachial endothelial response is not a hallmark of MS in young adults, but the status of endothelial function modifies the association between metabolic risk factors and atherosclerosis.
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Mattsson et al. (2007) conducted an observational in Metabolic syndrome (n=2,163). Metabolic syndrome vs. Subjects without the syndrome was evaluated on carotid artery intima-media thickness (cIMT) (p=<0.0001). Metabolic syndrome was associated with increased carotid intima-media thickness and decreased carotid artery compliance compared to those without the syndrome.
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