January 1, 1995Japanese Journal of ElectrocardiologyOpen Access

Antiarrhythmic effects of magnesium on coronary ligation induced arrhythmias in rats.

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Why the study?

Does intravenous magnesium reduce ventricular arrhythmias and mortality in a rat model of acute myocardial infarction?

Structured PICO

Does intravenous magnesium reduce ventricular arrhythmias and mortality in a rat model of acute myocardial infarction?

Population

Male Sprague-Dawley rats (body weight 200-280g) subjected to left coronary artery ligation as an acute myocardial infarction model.

Intervention

Intravenous magnesium (0.6 μM, 2 μM, 6 μM, 20 μM, or 60 μM) administered over 30 seconds, 5 minutes after coronary ligation.

Comparator

Intravenous physiological saline (equal volume) administered 5 minutes after coronary ligation.

Outcome

Total number of premature ventricular contractions (PVCs), duration of ventricular tachycardia (VT), incidence of VT, incidence of ventricular fibrillation (Vf), and mortality rate over 30 minutes post-ligation.surrogate

Limitations

The exact mechanism of the antiarrhythmic action could not be fully clarified.
Serum electrolytes measured at 30 minutes showed no significant differences, possibly because 25 minutes had passed since administration, missing earlier transient changes.

Implication

Intravenous magnesium administered after the onset of myocardial infarction suppresses hyperacute ventricular arrhythmias and reduces mortality in a rat coronary ligation model.

Abstract

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Discussion

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Cite This Study

Li et al. (1995) studied this question.

synapsesocial.com/papers/6a7ce65f6e07fdc915aeb320 https://doi.org/10.5105/jse.15.35

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Implication

Intravenous magnesium administered after the onset of myocardial infarction suppresses hyperacute ventricular arrhythmias and reduces mortality in a rat coronary ligation model.

Abstract

Mg)

Antiarrhythmic effects of magnesium on coronary ligation induced arrhythmias in rats.

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Antiarrhythmic effects of magnesium on coronary ligation induced arrhythmias in rats.

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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