Why the study?
Does prizidilol improve renal hemodynamics compared to propranolol in patients with mild-to-moderate essential hypertension?
Does prizidilol improve renal hemodynamics compared to propranolol in patients with mild-to-moderate essential hypertension?
Prizidilol is an effective hypotensive agent that, unlike propranolol, does not decrease renal plasma flow at rest or during exercise.
Prizidilol may be preferred over propranolol to preserve renal plasma flow in hypertension; extends RCT evidence on differential renal hemodynamics.
Effective renal plasma flow and glomerular filtration rate were measured in 22 mild-to-moderate, uncomplicated, essential hypertensive patients during placebo and after 3 months of randomly assigned treatment either with prizidilol (n = 10) or propranolol (n = 12). Measurements were performed at rest and during cycloergometer exercise. For a comparable effect on blood pressure effective renal plasma flow was significantly increased at rest by prizidilol (+9%) and decreased by propranolol (-13.6%); these patterns were maintained during exercise. Glomerular filtration rate was immodified after the treatment with both drugs. It is concluded that prizidilol is an effective hypotensive agent with no deleterious effects on renal haemodynamics.
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Malini et al. (1984) studied this question.
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