Why the study?
Does a single oral dose of prizidilol hydrochloride affect heart rate, blood pressure, and pulmonary function compared to propranolol and placebo in healthy volunteers?
Does a single oral dose of prizidilol hydrochloride affect heart rate, blood pressure, and pulmonary function compared to propranolol and placebo in healthy volunteers?
Prizidilol is a novel antihypertensive agent that lowers blood pressure via vasodilation without causing reflex tachycardia or airway obstruction in healthy subjects.
Answers are grounded in this paper and cite their sources.
May support prizidilol evaluation in hypertensives without reflex tachycardia or airway effects; extends early evidence for its dual vasodilatory action.
The effects on heart rate, blood pressure and pulmonary function of single oral doses of prizidilol hydrochloride (400 mg SK&F 92657) and propranolol (40 mg) were compared with placebo in nine healthy volunteers, in a double blind crossover study. Prizidilol had no effect on heart rate while propranolol caused a significant reduction compared with placebo. Diastolic blood pressure was lowered to the same extent by both prizidilol and propranolol. Propranolol significantly reduced the forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and the maximal expiratory flow at 50% vital capacity (MEF 50). Prizidilol had no effect on flow-volume loop parameters. Effective pulmonary blood flow was not altered by propranolol, but it was significantly increased by prizidilol. Oral prizidilol exerts its hypotensive effect by vasodilatation without reflex tachycardia. It does not cause airways obstruction in healthy subjects.
No takes yet. Share an insight, caveat, or question.
Edmondstone et al. (1983) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: