February 1, 1982British Journal of Clinical PharmacologyOpen Access

Renal haemodynamics after chronic treatment with labetalol and propranolol.

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Why the study?

Does labetalol or propranolol alter renal hemodynamics compared to placebo?

Population

24 patients (two groups of 12)

Comparison

Labetalol or propranolol for 3 months vs Placebo

Follow-up

3 months

Authors

PMP. L. MaliniIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola ESEnrico StrocchiUniversity of Bologna SNSilvana NegroniUniversity of Bologna

Discussion

Member takes

Implication

Labetalol may improve renal hemodynamics versus propranolol; hypothesis-generating and should not yet change practice.

Structured PICO

Does labetalol or propranolol alter renal hemodynamics compared to placebo?

Population

24 patients (two groups of 12)

Intervention

Labetalol or propranolol for 3 months

Comparator

Placebo

Outcome

Effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) at rest and during sub-maximal cycloergometer exercisesurrogate

Labetalol improves renal hemodynamics (increased ERPF and decreased vascular resistance) compared to propranolol, despite achieving similar blood pressure reductions.

Cite This Study

Malini et al. (1982) studied this question.

synapsesocial.com/papers/6a71e237ce524a4339c52f4e https://doi.org/10.1111/j.1365-2125.1982.tb01900.x

Topics

Hypertension management

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Renal haemodynamics after chronic treatment with labetalol and propranolol.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Renal haemodynamics after chronic treatment with labetalol and propranolol.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider