Why the study?
Endocardial radiofrequency catheter ablation for ventricular arrhythmia can be unsuccessful when lesions are intramural or subepicardial, requiring approaches beyond conventional techniques.
Chemical ablation using the double balloon technique with chronic total occlusion percutaneous coronary intervention techniques represents a potential approach for refractory ventricular tachycardia from the left ventricular summit.
Double-balloon ethanol infusion may enable ablation of refractory LV summit VT after failed endocardial RFA; leaves open need for prospective trials before wider use.
Endocardial radiofrequency catheter ablation (RFA) for ventricular arrhythmia (VA) is an established procedure with variable success rates. Compared to antiarrhythmic drugs such as amiodarone, sotalol, and β-blockers, endocardial substrate–based RFA reportedly improves survival rates in patients with ischemic cardiomyopathy.1 However, endocardial RFA may sometimes be unsuccessful, since 5%‒15 % of lesions are located in the intramural or subepicardial region, which may require interventions outside of conventional approaches.
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Ishiguro et al. (2023) studied this question.
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