Key points are not available for this paper at this time.
Rodent LPL shifts with cold may redirect lipid use; leaves open human cardiometabolic relevance.
The response of lipoprotein lipase (LPL) activity in rat epididymal fat, brown fat, heart, lung, liver, and postheparin plasma to cold exposure (4 C) for 1 and 28 days (cold acclimated) was examined. Whereas epididymal fat activity was markedly depressed (-85%) after only 1 day at 4C, large elevations in activity were found in brown fat (900%), heart (120%), lung (94%), and postheparin plasma (50%). These reciprocal changes persisted throughout acclimation. Liver showed no change. The findings suggest that the distribution between, and uptake of serum triglycerides by, extrahepatic tissues via LPL is altered by cold exposure to favor utilization and suppress deposition in the fat depots. Plasma insulin levels appear to be an important factor in the regulation of LPL activity in various tissues. (Author)
No takes yet. Share an insight, caveat, or question.
Radomski et al. (1971) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: