March 1, 2001Journal of Biological ChemistryOpen Access

Transcytosis of Lipoprotein Lipase across Cultured Endothelial Cells Requires Both Heparan Sulfate Proteoglycans and the Very Low Density Lipoprotein Receptor

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Structured PICO

Population

Cultured monolayers of bovine aortic endothelial cells

Intervention

Heparinase/heparinitase treatment, addition of heparin, receptor-associated protein, specific receptor antibodies (anti-VLDL receptor antibodies), and overexpression of VLDL receptor using adenoviral-mediated gene transfer

Comparator

Untreated/control cells

Outcome

Movement/transcytosis of LPL (measured by (125)I-LPL and LPL activity transfer)surrogate

Transcytosis of lipoprotein lipase across endothelial cells requires both heparan sulfate proteoglycans and the VLDL receptor.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

No immediate clinical implications; leaves open whether HSPG-VLDL receptor pathways mediate LPL transcytosis in humans.

Cite This Study

Obunike et al. (2001) studied this question.

synapsesocial.com/papers/6a7cec57c54fa5ab9c3b3bc5 https://doi.org/10.1074/jbc.m008813200

View Full Paper

Ask AI

Bookmark

Transcytosis of Lipoprotein Lipase across Cultured Endothelial Cells Requires Both Heparan Sulfate Proteoglycans and the Very Low Density Lipoprotein Receptor

Structured PICO

Discussion

Implication

Cite This Study

Transcytosis of Lipoprotein Lipase across Cultured Endothelial Cells Requires Both Heparan Sulfate Proteoglycans and the Very Low Density Lipoprotein Receptor

Structured PICO

Discussion

Implication

Cite This Study

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