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October 1, 2010Journal of Nephrology

Possible involvement of intracellular angiotensin II receptor in high-glucose-induced damage in renal proximal tubular cells

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Why the study?

Do ARBs reduce high-glucose-induced oxidative stress in renal proximal tubular epithelial cells?

Population

Renal proximal tubular epithelial cells (RPTECs)

Comparison

High glucose with ARBs (candesartan, olmesartan… vs Regular glucose medium (1.75x10 mol/L) or high…

Design

Preclinical

Authors

TTToshihiro TakaoKawasaki Medical SchoolTHTaro HorinoUnited States Bureau of ReclamationTKToru KagawaKōchi University

Discussion

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Implication

ARBs may attenuate tubular oxidative stress in hyperglycemia models; hypothesis-generating and should not yet change practice.

Structured PICO

Do ARBs reduce high-glucose-induced oxidative stress in renal proximal tubular epithelial cells?

P
Population
Renal proximal tubular epithelial cells (RPTECs)
I
Intervention
High glucose (4x10-2 mol/L) with ARBs (candesartan, olmesartan or valsartan; 1x10(-9)-10(-7) mol/L)
C
Comparator
Regular glucose medium (1.75x10(-2) mol/L) or high glucose without ARBs
O
Outcome
N-Acetyl-beta-glucosaminidase (NAG), angiotensin II, and 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentrations, and p22phox and cytoplasmic inhibitory kappa B (IkB) protein levelssurrogate

ARBs reduce high-glucose-induced oxidative stress in renal proximal tubular epithelial cells, suggesting a protective mechanism in diabetic nephropathy via intracellular AT1 receptor blockade.

Cite This Study

Takao et al. (2010) studied this question.

synapsesocial.com/papers/6a7cec6b8fc303b9e22fa70chttps://doi.org/10.5301/jn.2010.5785
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II–Induced Reactive Oxygen Species and the Kidney2007 · 280 citations
  2. 2Losartan and Angiotensin II Inhibit Aldosterone Production in Anephric Rats via Different Actions on the Intraadrenal Renin-Angiotensin System*1999 · 49 citations
  3. 3In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal renin angiotensin system.1990 · 325 citations
  4. 4Gene expression of the renin-angiotensin system in human kidney1998 · 114 citations
  5. 5Effects of angiotensin II on proximal tubular cells stably transfected with the c-mas oncogene1992 · 15 citations