Why the study?
Whether to treat minor stroke with intravenous t-PA or antiplatelet therapy remains a clinical dilemma.
Does intravenous t-PA improve functional outcomes compared to DAPT or aspirin in patients with acute minor ischemic stroke?
Population
Patients with acute minor stroke (NIHSS score 0-3 at randomisation)
Comparison
Intravenous t-PA vs DAPT vs aspirin
Design
Post hoc analysis
Follow-up
3 months
Authors
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No advantage of tPA over DAPT or aspirin seen in minor stroke; leaves open need for randomized trials.
Does intravenous t-PA improve functional outcomes compared to DAPT or aspirin in patients with acute minor ischemic stroke?
In patients with acute minor ischemic stroke, intravenous t-PA did not show a significant advantage over DAPT or aspirin for 3-month functional outcomes, though the study was limited by sample size.
Wang et al. (2020) studied this question.
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