Why the study?
Does ramipril reduce left ventricular hypertrophy in hypertensive patients on furosemide?
Population
115 patients with controlled or uncontrolled hypertension and left ventricular hypertrophy, on background…
Comparison
Ramipril 1.25 mg or 5 mg daily for 6 months… vs Placebo daily for 6 months, added to furosemide…
Design
RCT, randomized, double-blind
Follow-up
6 months
Authors
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Ramipril may be prioritized for LVH regression in furosemide-treated hypertension; extends ACEI evidence beyond BP lowering.
Does ramipril reduce left ventricular hypertrophy in hypertensive patients on furosemide?
Ramipril induces regression of left ventricular hypertrophy in hypertensive patients independent of its blood pressure-lowering effects.
Lièvre et al. (1995) studied this question.
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