Why the study?
Does Angiotensin II modulate erectile function and intracavernosal pressure in corpus cavernosum tissue?
Population
Human corpus cavernosum tissue samples and anesthetized dogs
Design
Preclinical
Authors
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Does not support ARB use for erectile dysfunction; leaves open translation of canine Ang II effects to humans.
Does Angiotensin II modulate erectile function and intracavernosal pressure in corpus cavernosum tissue?
The corpus cavernosum produces Angiotensin II locally, which acts to contract smooth muscle and terminate erections, suggesting a potential role for Ang II antagonists in treating erectile dysfunction.
Kifor et al. (1997) studied this question.
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