Angiotensin II Signaling and Its Implication in Erectile Dysfunction

INTRODUCTION: Angiotensin II (Ang II) is the primary effector of the renin-angiotensin system (RAS). Ang II exerts its diverse physiologic actions via angiotensin type 1 and type 2 receptors. Recent evidence shows that tissue RAS exists in the penis, therefore indicating a significant role for Ang II in erectile function. AIM: To summarize the recent findings on the importance of Ang II in normal erection physiology and the pathogenesis of erectile dysfunction (ED). METHODS: This article reviews the literature that relates to the role of RAS in the regulation of erectile function. MAIN OUTCOME MEASURES: Evidence in the literature on the association between Ang II and the development of ED. RESULTS: Elevated Ang II levels contribute to the development of ED in humans and different animal models. Pharmacologic therapy interrupting RAS may be beneficial for patients with ED. CONCLUSION: Studies have demonstrated that RAS is crucial in erectile function. Better understanding of the signaling pathways mediating Ang II physiologic actions will provide important information for the treatment of ED.