Concentrations of C-Reactive Protein and B-Type Natriuretic Peptide 30 Days after Acute Coronary Syndromes Independently Predict Hospitalization for Heart Failure and Cardiovascular Death
Why the study?
Do elevated concentrations of hsCRP and BNP 30 days after ACS predict hospitalization for heart failure and cardiovascular death?
Population
4162 patients stabilized after acute coronary syndromes randomized to intensive or moderate statin therapy
Comparison
Elevated high-sensitivity C-reactive protein and… vs Lower concentrations of hsCRP and BNP
Design
Cohort, Patients were randomized to either intensive or moderate statin therapy
Follow-up
mean 24 months
Authors
Discussion
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Member takes
Implication
Dual hsCRP-BNP elevation may aid post-ACS HF risk stratification; hypothesis-generating and requires prospective validation.
Structured PICO
Do elevated concentrations of hsCRP and BNP 30 days after ACS predict hospitalization for heart failure and cardiovascular death?
P
Population
4162 patients stabilized after acute coronary syndromes (ACS) randomized to intensive or moderate statin therapy
I
Intervention
Elevated high-sensitivity C-reactive protein (hsCRP >2.0 mg/L) and B-type natriuretic peptide (BNP >80 ng/L) measured 30 days after randomization
C
Comparator
Lower concentrations of hsCRP and BNP
O
Outcome
Hospitalizations for heart failure and cardiovascular death occurring after day 30hard clinical
Elevated hsCRP and BNP levels 30 days post-ACS independently and synergistically predict subsequent heart failure hospitalization and cardiovascular death.
Cite This Study
Scirica et al. (2008) studied this question.