Why the study?
The causal effect of blood pressure traits and blood pressure-lowering medications on peripheral artery disease remained to be determined.
Does genetic variation associated with higher blood pressure or blood pressure-lowering medications affect the risk of peripheral artery disease?
Population
Genome-wide association studies summary statistics for BP, PAD, and coronary artery disease
Comparison
Genetically predicted BP traits and BP-lowering medications
Design
Two-sample Mendelian randomization study
Authors
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Supports BP lowering for PAD prevention; leaves open medication effects and requires trial confirmation.
Does genetic variation associated with higher blood pressure or blood pressure-lowering medications affect the risk of peripheral artery disease?
Genetic evidence suggests that higher blood pressure causally increases the risk of peripheral artery disease, and blood pressure-lowering medications may offer protective effects.
Levin et al. (2021) studied this question.
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