Why the study?
Does ramatroban reduce macrophage accumulation and neointimal formation after balloon arterial injury in cholesterol-fed rabbits?
Population
21 New Zealand white rabbits fed a cholesterol-rich diet for 4 weeks with abdominal aorta injured by a…
Comparison
Ramatroban 1 or 5 mg/kg daily for 4 weeks vs Saline
Design
Preclinical, randomized
Follow-up
4 weeks
Authors
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Ramatroban effects in atherosclerotic rabbits warrant human translation studies; should not yet alter clinical restenosis management.
Does ramatroban reduce macrophage accumulation and neointimal formation after balloon arterial injury in cholesterol-fed rabbits?
In an atherosclerotic rabbit model, TXA2 receptor blockade with ramatroban prevents macrophage infiltration and neointimal formation after balloon injury, suggesting a potential mechanism to reduce restenosis.
Ishizuka et al. (2003) studied this question.
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