January 1, 2008Circulation JournalOpen Access

Angiotensin-Receptor Blockade Reduces Border Zone Myocardial Monocyte Chemoattractant Protein-1 Expression and Macrophage Infiltration in Post-Infarction Ventricular Remodeling

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Why the study?

Does candesartan reduce myocardial MCP-1 expression and macrophage infiltration in Wistar rats with post-infarction ventricular remodeling?

Population

Wistar rats with myocardial infarction produced by ligation of the left coronary artery

Comparison

Candesartan for 6 weeks or for 2 weeks starting… vs Vehicle

Design

Preclinical, randomized

Follow-up

6 weeks

Authors

TKTakashi KohnoNational Cancer Centre Japan TAToshihisa AnzaiHeart Failure & Transplant KNKotaro NaitoKyushu University

Discussion

Member takes

Implication

Candesartan may attenuate post-MI inflammation and fibrosis in rats; leaves open translation to human ventricular remodeling.

Structured PICO

Does candesartan reduce myocardial MCP-1 expression and macrophage infiltration in Wistar rats with post-infarction ventricular remodeling?

Population

Wistar rats with myocardial infarction produced by ligation of the left coronary artery

Intervention

Candesartan (10 mg/kg/day) for 6 weeks or for 2 weeks starting 4 weeks after MI

Comparator

Vehicle

Outcome

LV systolic and end-diastolic pressures, mRNA expressions of MCP-1, transforming growth factor-beta1, and procollagen type I and III, macrophage infiltration, and myocardial fibrosis in the border zone at 6 weekssurrogate

In a rat model of post-MI heart failure, candesartan attenuated MCP-1 expression and macrophage infiltration, leading to reduced myocardial fibrosis.

Cite This Study

Kohno et al. (2008) studied this question.

synapsesocial.com/papers/6a7ec6842540bc8e230269e2 https://doi.org/10.1253/circj.cj-08-0115

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Angiotensin-Receptor Blockade Reduces Border Zone Myocardial Monocyte Chemoattractant Protein-1 Expression and Macrophage Infiltration in Post-Infarction Ventricular Remodeling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin-Receptor Blockade Reduces Border Zone Myocardial Monocyte Chemoattractant Protein-1 Expression and Macrophage Infiltration in Post-Infarction Ventricular Remodeling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider