Why the study?
Systemic inflammation plays a central role in HFpEF, and low-level transcutaneous vagus nerve stimulation suppresses inflammation via an alpha7 nicotinic acetylcholine receptor pathway, prompting investigation of its effects on cardiac function, inflammation, and fibrosis.
Does low-level transcutaneous vagus nerve stimulation improve cardiac function and reduce inflammation in a rat model of HFpEF?
Population
Dahl salt-sensitive rats with high-salt diet-induced HFpEF
Comparison
LLTS vs LLTS with methyllycaconitine vs sham vs olmesartan
Design
Preclinical animal study
Follow-up
4 weeks
Authors
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LLTS benefits in HFpEF rats support mechanistic studies; leaves open translation and α7nAchR dependence in humans.
Does low-level transcutaneous vagus nerve stimulation improve cardiac function and reduce inflammation in a rat model of HFpEF?
Neuromodulation with low-level transcutaneous vagus nerve stimulation improved cardiac function, inflammation, and fibrosis in a rat model of HFpEF via an α7nAchR-dependent pathway.
Elkholey et al. (2022) studied this question.
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