March 1, 2003AJP Cell Physiology

Peroxynitrite and nitric oxide differ in their effects on pig coronary artery smooth muscle

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Population

Pig coronary artery (deendothelialized artery rings), cultured cells, and isolated membrane vesicles

Comparison

Pretreatment with peroxynitrite and… vs Control/baseline and comparison between…

Design

Preclinical

Authors

MWMandeep Kaur WaliaGuru Nanak Dev University SSSue E. SamsonHuntsman Cancer Institute TSTracey SchmidtMcMaster University

Discussion

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Implication

May guide mechanistic studies of coronary vasoregulation; leaves open translation to human disease.

Structured PICO

Population

Pig coronary artery (deendothelialized artery rings), cultured cells, and isolated membrane vesicles

Intervention

Pretreatment with peroxynitrite and peroxynitrite/NO-generating agents (SIN-1, SNAP, SNP, and NONOate) at 200 microM

Comparator

Control/baseline (implied) and comparison between different agents

Outcome

Force of contraction in response to cyclopiazonic acid (CPA) and 30 mM KCl, Ca(2+) transients, and Ca(2+) uptake by the SERCA pumpsurrogate

Peroxynitrite and NO both inhibit CPA-induced contractions in pig coronary arteries through different mechanisms, with peroxynitrite damaging the SERCA pump and NO acting downstream of cytosolic Ca2+ increases.

Cite This Study

Walia et al. (2003) studied this question.

synapsesocial.com/papers/6a7d16440ae9e6500d83d503 https://doi.org/10.1152/ajpcell.00405.2002

Topics

Coronary artery disease Coronary CT angiography

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Peroxynitrite and nitric oxide differ in their effects on pig coronary artery smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Peroxynitrite and nitric oxide differ in their effects on pig coronary artery smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider