Population
Human coronary arterioles dissected from right atrial appendages and isolated vascular smooth muscle cells
Comparison
Peroxynitrite or ONOO- generating system vs Decomposed ONOO-, superoxide alone, or control…
Design
Preclinical
Authors
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May impair coronary vasomotor function via KCa inhibition; hypothesis-generating for endothelial dysfunction in ischemia/reperfusion.
Peroxynitrite directly inhibits calcium-activated K+ channel activity in human coronary vascular smooth muscle cells, impairing vasodilation, which may contribute to endothelial dysfunction in conditions like ischemia/reperfusion.
Liu et al. (2002) studied this question.
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