May 1, 1997British Journal of PharmacologyOpen Access

Characterization of the vasodilator properties of peroxynitrite on rat pulmonary artery: role of poly (adenosine 5′‐diphosphoribose) synthase

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Why the study?

Does peroxynitrite cause vasodilatation in isolated rat pulmonary arteries via PARS activation?

Population

Isolated pulmonary artery rings from rats

Comparison

Peroxynitrite added cumulatively, with or… vs Vehicle, decayed ONOO-, or baseline tone

Design

Preclinical

Authors

FCF. ChabotInserm JMJane A. MitchellVascular / Pulmonary Vascular GQGregory J. QuinlanLung Institute

Discussion

Member takes

Implication

Hypothesis-generating for PARS inhibition in sepsis hypotension; human studies required before clinical consideration.

Structured PICO

Does peroxynitrite cause vasodilatation in isolated rat pulmonary arteries via PARS activation?

Population

Isolated pulmonary artery rings from rats

Intervention

Peroxynitrite (ONOO-) (10 nM-100 microM) added cumulatively, with or without PARS inhibitor 3-aminobenzamide (10 microM), L-NAME (100 microM), or superoxide dismutase (30 units ml-1)

Comparator

Vehicle, decayed ONOO-, or baseline tone

Outcome

Pulmonary vascular tone (vasodilatation/relaxation)surrogate

Peroxynitrite causes vasodilatation of rat pulmonary arteries via activation of PARS, suggesting PARS inhibitors may reduce persistent hypotension in sepsis.

Cite This Study

Chabot et al. (1997) studied this question.

synapsesocial.com/papers/6a890f3fcd9902a7ca127100 https://doi.org/10.1038/sj.bjp.0701162

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Characterization of the vasodilator properties of peroxynitrite on rat pulmonary artery: role of poly (adenosine 5′‐diphosphoribose) synthase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of the vasodilator properties of peroxynitrite on rat pulmonary artery: role of poly (adenosine 5′‐diphosphoribose) synthase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider