Population
Anesthetized Sprague-Dawley rats
Comparison
Intrarenal administration of NOX inhibitor… vs Control conditions
Design
Preclinical
Authors
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Should not alter clinical vasoconstriction management; extends animal data on NOX superoxide but leaves human relevance open.
NOX-derived superoxide substantially contributes to basal renal blood flow and acute renal vasoconstrictor responses to angiotensin II and catecholamines independently of nitric oxide scavenging.
Just et al. (2006) studied this question.
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