Superoxide scavenging attenuates renal responses to ANG II during nitric oxide synthase inhibition in anesthetized dogs

Anesthetized dogs pretreated with enalaprilat (33 microg x kg(-1) x min(-1)), n=13

Intra-arterial infusion of ANG II (0.5 ng x kg(-1) x min(-1)) during administration of a superoxide dismutase mimetic, tempol (0.5 mg x kg(-1) x min(-1)), in the presence or absence of NO synthase inhibitor, nitro-L-arginine (NLA; 50 microg x kg(-1) x min(-1))

Intra-arterial infusion of ANG II before tempol administration

Renal blood flow (RBF), urine flow (V), urinary sodium excretion (U(Na)V), and glomerular filtration rate (GFR)surrogate