November 4, 2003HypertensionOpen Access

Role of Superoxide in Modulating the Renal Effects of Angiotensin II

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Population

Preclinical in vivo model and renal homogenates

Design

Preclinical

Authors

BABernardo López AndradeHealth Research Institute of the Balearic Islands MSMiguel G. SalomCross-Cutting Cardiology BABegoña ArreguiUniversity of the Basque Country

Discussion

Member takes

Implication

Supports NADPH oxidase mediation of Ang II renal effects in rodents; leaves open translation to human hypertension therapies.

Structured PICO

Population

Preclinical in vivo model and renal homogenates

Intervention

Tempol (superoxide dismutase mimetic), apocynin (NADPH inhibitor), valsartan, and Angiotensin II infusion

Outcome

Renal cortical nitric oxide (NO) levels, renal blood flow, glomerular filtration rate, sodium excretion, and superoxide (O2-) generationsurrogate

Angiotensin II's acute renal vasoconstrictor and antinatriuretic effects are partially mediated by NADPH oxidase-dependent superoxide generation, which reduces nitric oxide bioavailability.

Cite This Study

Andrade et al. (2003) studied this question.

synapsesocial.com/papers/6a7e85cce7861671be8ec21f https://doi.org/10.1161/01.hyp.0000101968.09376.79

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Role of Superoxide in Modulating the Renal Effects of Angiotensin II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of Superoxide in Modulating the Renal Effects of Angiotensin II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider