March 1, 1997AJP Heart and Circulatory Physiology

Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency

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Why the study?

Does peroxynitrite impair cardiac contractile function and energy metabolism in isolated rat hearts?

Structured PICO

Does peroxynitrite impair cardiac contractile function and energy metabolism in isolated rat hearts?

Population

Isolated working rat hearts

Intervention

Peroxynitrite (ONOO-) (4 or 40 microM) or NO donor S-nitroso-DL-acetylpenicillamine (SNAP) (40 microM) infused over a 60-min period

Comparator

Vehicle control

Outcome

Cardiac function (cardiac work, coronary flow, cardiac efficiency) and energy metabolism (O2 consumption, glycolysis, glucose oxidation, pyruvate oxidation)surrogate

Peroxynitrite impairs cardiac efficiency in isolated rat hearts, likely due to reduced coupling between ATP production and mechanical work.

Discussion

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Implication

Peroxynitrite impairs efficiency in isolated rat hearts; hypothesis-generating for its role in human HF, with no clinical implications yet.

Cite This Study

Schulz et al. (1997) studied this question.

synapsesocial.com/papers/6a71466e2163a0a01bc56e7b https://doi.org/10.1152/ajpheart.1997.272.3.h1212

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Implication

Peroxynitrite impairs efficiency in isolated rat hearts; hypothesis-generating for its role in human HF, with no clinical implications yet.

Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency

Structured PICO

Discussion

Implication

Cite This Study

Peroxynitrite impairs cardiac contractile function by decreasing cardiac efficiency

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider