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May 4, 1998Circulation Research

Inhibition of Rat Cardiac Muscle Contraction and Mitochondrial Respiration by Endogenous Peroxynitrite Formation During Posthypoxic Reoxygenation

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Population

Isolated rat left ventricular posterior papillary muscle and rat left ventricular cardiac muscle

Comparison

Posthypoxic reoxygenation with or without… vs Control conditions or comparison between…

Design

Preclinical

Follow-up

Up to 1 hour after reoxygenation

Authors

YXYi-Wu XieQingdao UniversityPKPawel M. KaminskiAndrzej Frycz Modrzewski Krakow UniversityMWMichael S. WolinNew York Medical College

Discussion

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Implication

Peroxynitrite may mediate posthypoxic cardiac dysfunction in vitro; hypothesis-generating for targeted therapies in reperfusion injury.

Structured PICO

P
Population
Isolated rat left ventricular posterior papillary muscle and rat left ventricular cardiac muscle
I
Intervention
Posthypoxic reoxygenation (15 minutes of hypoxia followed by reintroduction of O2) with or without pharmacological agents (nitro-L-arginine, superoxide dismutase, urate, mannitol, SNAP, pyrogallol, bradykinin, NaCN)
C
Comparator
Control conditions or comparison between different pharmacological agents
O
Outcome
Isometric contraction (cardiac muscle contractility) and O2 uptake (mitochondrial respiration)surrogate

Endogenous peroxynitrite formation contributes to the inhibition of cardiac muscle contractility and mitochondrial respiration during posthypoxic reoxygenation.

Cite This Study

Xie et al. (1998) studied this question.

synapsesocial.com/papers/6a7205c131a3df824329ebf7https://doi.org/10.1161/01.res.82.8.891
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