Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure: An analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programme
Why the study?
Does diabetes increase the risk of cardiovascular death or heart failure hospitalization differently in patients with low versus preserved ejection fraction heart failure?
Population
7599 patients with symptomatic heart failure and a broad range of ejection fraction
Comparison
Presence of diabetes vs Absence of diabetes
Design
Cohort
Authors
Discussion
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Member takes
Implication
May support EF-stratified risk assessment in diabetic HF; hypothesis-generating and should not yet change practice.
Structured PICO
Does diabetes increase the risk of cardiovascular death or heart failure hospitalization differently in patients with low versus preserved ejection fraction heart failure?
P
Population
7599 patients with symptomatic heart failure and a broad range of ejection fraction (low EF <=40% and preserved EF >40%)
I
Intervention
Presence of diabetes
C
Comparator
Absence of diabetes
O
Outcome
Composite of cardiovascular death or heart failure hospitalizationcomposite
Diabetes confers a significantly greater relative risk of cardiovascular death or heart failure hospitalization in patients with preserved ejection fraction compared to those with reduced ejection fraction.
Cite This Study
MacDonald et al. (2008) studied this question.