Why the study?
Few studies have compared the associations between diabetes mellitus and cardiac remodeling, quality of life, and clinical outcomes according to heart failure phenotype.
Does type 2 diabetes mellitus worsen cardiac remodeling, quality of life, and clinical outcomes in patients with HFrEF and HFpEF?
Population
5028 HFrEF and 1139 HFpEF patients, plus community-based controls without HF
Comparison
With vs without type 2 diabetes mellitus across HF phenotypes
Design
Prospective registry study
Follow-up
1-year
Authors
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Diabetes links to adverse remodeling, poorer QoL, and worse outcomes across HF phenotypes; leaves open targeted interventions.
Does type 2 diabetes mellitus worsen cardiac remodeling, quality of life, and clinical outcomes in patients with HFrEF and HFpEF?
Type 2 diabetes mellitus is associated with adverse cardiac remodeling, poorer quality of life, and worse 1-year clinical outcomes in both HFrEF and HFpEF patients.
Yap et al. (2019) studied this question.
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