July 1, 1999AJP Heart and Circulatory Physiology
Potentiation of stretch-induced atrial natriuretic peptide secretion by intracellular acidosis
Why the study?
Does intracellular acidosis potentiate stretch-induced ANP secretion and alter contraction force in isolated rat atria?
Population
Isolated rat atria
Comparison
Propionate-induced intracellular acidosis… vs Nonacidotic control atria subjected to stretch
Design
Preclinical
Authors
Discussion
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Member takes
Implication
ANP secretion may mark atrial ischemia; hypothesis-generating for contractile dysfunction and requires in vivo human validation.
Structured PICO
Does intracellular acidosis potentiate stretch-induced ANP secretion and alter contraction force in isolated rat atria?
P
Population
Isolated rat atria
I
Intervention
Propionate (20 mM)-induced intracellular acidosis combined with stretch (increasing intra-atrial pressure from 1 to 4 mmHg)
C
Comparator
Nonacidotic control atria subjected to stretch
O
Outcome
Stretch-induced changes in atrial natriuretic peptide (ANP) secretion, contraction force, and intracellular Ca(2+) concentrationsurrogate
Intracellular acidosis potentiates stretch-induced ANP secretion while decreasing contraction force, suggesting ANP secretion may serve as an indicator of contractile dysfunction during ischemia.
Cite This Study
Tavi et al. (1999) studied this question.