Why the study?
Does intracellular acidosis modulate stretch-induced changes in excitation-contraction coupling in isolated rat atria?
Population
Isolated rat atria (n=6 to 13 depending on the experiment)
Comparison
Intracellular acidosis induced by 20 mmol L-1… vs Stretch in normal pH (non-acidotic control)
Design
Preclinical
Authors
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Acidosis modulates stretch responses in rat atria; hypothesis-generating for human mechanotransduction and arrhythmogenesis.
Does intracellular acidosis modulate stretch-induced changes in excitation-contraction coupling in isolated rat atria?
Intracellular acidosis modulates mechanotransduction in rat atria by interfering with intracellular Ca2+ balance and inhibiting Ca2+ extrusion mechanisms.
Tavi et al. (1999) studied this question.
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