Why the study?
Does bleomycin improve clinical efficacy and reduce toxicity compared to doxycycline in adult patients with malignant pericardial effusion and cardiac tamponade?
Population
27 consecutive adult patients with malignant pericardial effusion and cardiac tamponade, median age 59…
Comparison
Bleomycin pericardial sclerosis. vs Doxycycline pericardial sclerosis.
Design
Other, alternately assigned
Authors
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May favor bleomycin for lower pain in pericardial sclerosis; hypothesis-generating and requires randomized confirmation.
Does bleomycin improve clinical efficacy and reduce toxicity compared to doxycycline in adult patients with malignant pericardial effusion and cardiac tamponade?
Bleomycin is as effective as doxycycline for pericardial sclerosis in malignant pericardial effusion but is associated with significantly less morbidity, making it a preferred first-line agent.
Liu et al. (1996) studied this question.
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