Why the study?
The genetic influence on arrhythmia risk in hypertrophic cardiomyopathy remains unclear.
Are pathogenic genetic variants associated with higher rates of ventricular tachycardia and poor sinus rhythm maintenance in atrial fibrillation in patients with hypertrophic cardiomyopathy?
Are pathogenic genetic variants associated with higher rates of ventricular tachycardia and poor sinus rhythm maintenance in atrial fibrillation in patients with hypertrophic cardiomyopathy?
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Pathogenic genetic variants in HCM patients are associated with increased risk of ventricular tachycardia and poor sinus rhythm maintenance in atrial fibrillation, suggesting a need for genotype-tailored arrhythmia management.
The genetic influence on arrhythmia risk in hypertrophic cardiomyopathy (HCM) remains unclear.In this retrospective HCM cohort analysis, pathogenic genetic variants were associated with higher rates of ventricular tachycardia and poor sinus rhythm maintenance in atrial fibrillation.This finding suggests a need for tailored diagnostic and therapeutic approach for arrhythmia based on individual genetic profile in HCM patients.
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Kim et al. (2026) studied this question.
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