September 1, 1974Circulation Research
Participation of Central Serotonergic Neurons in the Control of the Circulation of the Unanesthetized Rabbit
Why the study?
Does central serotonergic neuron degeneration via 5,6-DHT alter blood pressure and heart rate in normal and hypertensive rabbits?
Population
Unanesthetized rabbits (normal, with sinoaortic denervation, and with experimental renal hypertension)
Comparison
Intracisternal injection of… vs Vehicle-injected controls
Design
Preclinical
Follow-up
1 week
Authors
Discussion
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Member takes
Implication
Does not support clinical translation; leaves open central serotonergic roles in human neurogenic versus renal hypertension.
Structured PICO
Does central serotonergic neuron degeneration via 5,6-DHT alter blood pressure and heart rate in normal and hypertensive rabbits?
P
Population
Unanesthetized rabbits (normal, with sinoaortic denervation, and with experimental renal hypertension)
I
Intervention
Intracisternal injection of 5,6-dihydroxytryptamine (5,6-DHT, 300 µg/kg)
C
Comparator
Vehicle-injected controls
O
Outcome
Mean arterial blood pressure and heart ratesurrogate
Central serotonergic neurons participate in the baroreceptor reflex arc and are necessary for the development of sustained neurogenic hypertension but not experimental renal hypertension in rabbits.
Cite This Study
Wing et al. (1974) studied this question.