May 1, 1982Journal of Cardiovascular Pharmacology

Cardiovascular Functions of Brain Serotonergic Neurons in the Rabbit as Analysed from the Acute and Chronic Effects of 5,6-Dihydroxytryptamine

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Population

Conscious rabbits (intact and decerebrate)

Comparison

Intracisternal 5,6-dihydroxytryptamine vs Creatinine sulphate vehicle

Design

Preclinical

Follow-up

Up to 14 days

Authors

GHGeoffrey A. HeadPreventive Cardiology PKPaul KörnerAgile Therapeutics (United States)

Discussion

Member takes

Implication

Central serotonergic effects on baroreflex in rabbits warrant no clinical extrapolation; leaves open translational relevance for human autonomic therapies.

Structured PICO

Population

Conscious rabbits (intact and decerebrate)

Intervention

Intracisternal (i.c.) 5,6-dihydroxytryptamine (5,6-DHT)

Comparator

Creatinine sulphate vehicle

Outcome

Mean arterial pressure (MAP), heart rate, baroreceptor-heart rate reflex properties, and nasopharyngeal reflex propertiessurrogate

Central serotonergic neurons inhibit cardiac vagal activity, increase blood pressure through suprapontine and bulbar/spinal pathways, and are involved in the nasopharyngeal reflex in rabbits.

Cite This Study

Head et al. (1982) studied this question.

synapsesocial.com/papers/6a86dce07fdf9298f89eb941 https://doi.org/10.1097/00005344-198205000-00010

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Implication

Central serotonergic effects on baroreflex in rabbits warrant no clinical extrapolation; leaves open translational relevance for human autonomic therapies.